BIOGRAPHICAL SKETCH

Academic & Professional Background

• B.A.(Chemistry) 1961 - Oberlin College, Ohio
• Fellow (Neuropsychopharmacology) 1965 - Institute of Psychiatry, University of London
• M.D.(Medicine) 1966 - University of Rochester, New York
• Residency (Psychiatry) 1973 - University of Chicago, Illinois

Current Research Interests

• Aging
• Brain-Immune System Interactions
• Clinical Trials
• Mechanisms of Toxicity of Environment Agents
• Neuropharmacology of PTSD; Panic Disorder
• Pharmacotherapy of Schizophrenia

Selected Publications

Rosenheck R, Lawson W, Crayton J, Cramer J, Xu W, Thomas J, Stolar M, Charney D. Predictors of differential response to clozapine and haloperidol. Biol Psychiatry 44:475-482, 1998.

Daghestani AN, Elenz E, Crayton JW. The coincidence of substance abuse and pathological gambling. J Clin Psychiatry 57:360-363, 1996.

Konopka LM, Cooper R, Crayton JW. Exaggerated response to serotonin of platelet cytosolic calcium in depressed, schizophrenic and substance abuse patients. Biological Psychiatry 39:708-713, 1996.

Crayton JW, Arora RC, Yeoh H, Wolf WW. Corticosterone effects on serotonin receptors in frontal cortex of the rat. Brain Research 728:260-262, 1996.

Young MR, Farietta T, Crayton JW. Production of nitric oxide and transforming growth factor-B in developing an adult rat brain. Mechanisms Aging Develop 79:115-126, 1995.

Papatheofanis FJ, Shirazi PH, Konopka LM, Crayton JW. Unusual Tc-99m HMPAO SPECT brain patterns in neurologic and neuropsychiatric disorders. Radio Graphics CD Suppl 15:5 Part 3, 1995.

Fichtner CG, O'Connor FL, Yeoh HC, Arora RC, Crayton JW. Hypodensity of platelet serotonin uptake sites in post traumatic stress disorder: Associated clinical features. Life Sci 57:PL37-44, 1995.

Fichtner CG, Arora RC, O'Connor FL, Crayton JW. Platelet paroxetine binding and fluoxetine pharmacotherapy in post traumatic stress disorder: Preliminary observations on a possible predictor of clinical treatment response. Life Sciences Pharmacology Letters 54:39-44, 1994.

Reid RW, O'Connor FL, Crayton JW. The in vitro differential binding of benzoylecgonine to pigmented human hair samples. J Toxicology Clin Tox 32:405-410, 1994.

Gulati A, Arora RC, Crayton JW. Characteristics of central serotonergic uptake sites in hypertensive rats: Interaction with clonidine and centhaquin. Eur J Pharmacol 231:151-156, 1993.

Tutton C, Crayton JW. Current pharmacotherapies for cocaine abuse: A review. J Addict Disorders 12:109-127, 1993.

Arora RC, Fichtner CG, O'Connor F, Crayton JW. Platelet serotonin binding and uptake in post-traumatic stress disorder. Life Sciences, 53:919-928, 1993.

Fichtner CG, Crayton JW. Buspirone treatment in post-traumatic stress disorder. J Clin Psychiatry 14:79-80, 1993.

Arora RC, Gulati A, Crayton JW. Aging and 3H-paroxetine binding in rat brain: Effect of imipramine and tetrahydroacridine. Life Sci 52:1767-1775, 1993.

Kut JL, Young RI, Crayton JW, Wright MA, Young ME. Regulation of murine T-lymphocyte function by spleen cell-derived and exogenous serotonin. Immunopharmacol Immunotoxicol 14(4):783-796, 1992.

Projects Completed or Active (Selected)

• The Clinical and Economic Impact of Clozaril Treatment in Chronic Schizophrenic Patient
• Serotonergic Abnormalities in Alzheimer's Disease
• Regional Cerebral Blood Flow in Cocaine Addicts
• Risperidone QD vs BID Dosing in Schizophrenia
• An Open-Label Assessment of the Long-Term Safety of Sertindole

Research Funding Sources

• Abbott Laboratories
• Chicago Consortium for Psychiatric Research
• Janssen
• National Institute on Drug Abuse
• The Potts Foundation
• VA Health Services Research and Development
• Stanley Foundation
• Zeneca

Research Methods Employed

• Drug Treatment Research with Psychotropic Drugs
• Electrophysiological Methods-EMG, Evoked Potentials-In Human Neuropharmacology Research
• Intensive "Own-Control" Human Study Designs
• Neurobehavioral Testing Methods

Professional Accomplishments

• 1986-present - Member, Illinois Governor's Medical Review Council