BIOGRAPHICAL SKETCH

Academic & Professional Background

• B.S.(Biology) 1967 - Loyola University, Chicago, Illinois
• M.D. 1971 - Northwestern University Medical School, Chicago, Illinois

Current Research Interests

• Aging
• Clinical Trials
• Diabetes Mellitus
• Neuroendocrine Effects of Ethanol

Selected Publications

Emanuele NV, LaPaglia N, Steiner J, Kirsteins L, Emanuele MA. The effect of chronic EtOH exposure on female rat reproductive cyclicity, hormone secretion and gene expression. Alcohol Clin Exp Res (accepted for publication), 2001.

Emanuele NV, LaPaglia N, Steiner J, Colantoni A, VanThiel DH, Emanuele MA. Peripubertal paternal EtOH exposure: Testicular oxidative injury, fecundity & offspring. Endocrine 14:213-219, 2001.

Zhu QL, Meisinger J, Emanuele NV, Emanuele MA, Fortuno F, VanThiel DH. Ethanol exposure enhances apoptosis within the testes. Alcohol: Clin Exp Res (accepted), 2000.

Emanuele NV, LaPaglia N, Vogl W, Steiner J, Kirsteins L, Emanuele MA. Impact and reversibility of chronic ethanol feeding on the reproductive axis in the peripubertal male rat. Endocrine (in press), 2000.

Colantoni A, LaPaglia N, DeMaria N, Emanuele MA, Emanuele NV, Harig H, Van Thiel DH. Influence of sex hormonal status on alcohol-induced oxidative injury in male and female rat liver. Alcohol: Clin Exp Res (in press), 2000.

Levin SR, Coburn JW, Abraira C, Henderson WG, Colwell JS, Emanuele NV, Nuttal FQ, Sawin CT, Comstock JP, Silbert CK. Effect of intensive glycemic control on microalbuminuria in Type 2 Diabetes. Diabetes Care. 23:1478-1485, 2000.

Pitale SU, Abraira C, Emanuele NV, McCarren M, Henderson WG, Pacold I, Bushnell D. Colwell JA, Nuttall FQ, Levin SR, Sawin CT, Comstock JP, Silbert CK. Two years of intensive glycemic control and left ventricular function in the Veterans Affairs Cooperative Study in Type 2 Diabetes Mellitus (VA CSDM). Diabetes Care 23:1316-1320, 2000.

Emanuele MA, Steiner J, LaPaglia N, Emanuele NV. Reversal of chronic EtOH-induced gonadal suppression by nalrexone. Alcoholism: Clin Exp Res 23:60-66, 1999.

Emanuele MA, LaPaglia N, Steiner J, Kirsteins L, Emanuele NV. Effects of nitric oxide synthase blockade on the acute response of the reproductive axis to ethanol in pubertal male rats. Alcoholism: Clin Exp Res 23:870-877, 1999.

Wezeman FH, Emanuele MA, Emanuele NV, Moskal SF, Woods M, Suri M, Steiner J, LaPaglia N. Chronic alcohol consumption during male rat adolescence impairs skeletal development through effects on osteoblast gene expression, bone mineral density and bone strength. Alcohol: Clin Exp Res 23:1534-1542, 1999.

Emanuele N, Azad N, Abraira C, Henderson W, Colwell J, Levin S, Nuttall F, Comstock J, Sawin C, Silbert C, Marcovina S, Lee HS. Effect of intensive glycemic control on fibrinogen, lipids and lipoproteins (Veterans Affairs Cooperative Study in Type II Diabetes Mellitus). Arch Intern Med 158:2485-2490, 1998.

Abraira C, Colwell J, Nuttall F, Sawin CT, Henderson W, Comstock JP, Emanuele NV, et al. Cardiovascular events and correlates in the Veterans Affairs Diabetes Feasibility Trial. Veterans Affairs Cooperative Study on Glycemic control and complications in type II diabetes. Archives of Internal Medicine 157:181-188, 1997.

Bayrakdar A, Gordon DL, Emanuele NV. Primary hypothalamic lymphoma mimicking sarcoidosis. The Endocrinologist 7:69-71, 1997.

Emanuele NV, Jurgens J, LaPaglia N, Williams DW, Kelley MR. The effect of castration on steady state levels of luteinizing hormone releasing hormone (LHRH) mRNA and pro-LHRH processing: Time course study utilizing semiquantitative reverse transcription/polymerase gene reaction. Journal of Endocrinology 148:509-515, 1996.

Uddin S, Wilson T, Emanuele MA, Kelley MR, Emanuele NV. Ethanol induced alterations in the post-translational processing but not secretion of LHRH in vitro. Alcoholism: Clin Exp Res 20:556-569, 1996.

Steiner J, Halloran MM, Jabamoni K, Emanuele NV, Emanuele MA. Sustained effects of a single injection of ethanol (ETOH) on the hypothalamic-pituitary-gonadal (HPG) axis in the male rat. Alcoholism: Clinical and Experimental Research 20:1368-1374, 1996.

Emanuele NV, Klein R, Abraira C, et al. Evaluations of retinopathy in the VA Cooperative Study on glycemic control and complications in type II diabetes (VA CSDM). Diabetes Care 19:1375-138, 1996.

Emanuele NV, Levey AD, Li W, Kirsteins L, Van de Kar LD. The impact of cocaine on plasma growth hormone levels in the adult male rate. Endocrine Research 22:139-145, 1996.

Emanuele MA, Halloran MM, Tentler JJ, Emanuele NV, Kelley MR. The effect of ethanol on male rodent reproduction and growth. In: Drug and Alcohol Abuse Reviews 6: Alcohol and Hormones. Watson R. (Ed.), Humana Press, Inc., Totowa, NJ, pp. 97-126, 1995.

Halloran MM, Tentler JJ, Emanuele NV, Kelley MR, Emanuele MA. Further characterization of the impact of ethanol on B-LH: Alterations in polyribosome association of B-LH mRNA. Endocrine 3:469-473, 1995.

Uddin S, Kirsteins L, LaPaglia N, Emanuele NV, Lawrence AM, Kelley MR, Emanuele MA. Failure of ethanol metabolites to alter gonadotropin secretion of luteinizing hormone synthesis in vitro. Endo Res 21(3), 1995.

Mohagheghpour N, Abel K, LaPaglia N, Emanuele N, Azad N. Signal requirements for production of luteinizing hormone releasing-hormone by human T cells. Cellular Immunology 163:280-288, 1995.

Abraira C, Colwell J, Nuttall F, Sawin C, Johnson-Nagel N, Comstock J, Emanuele N, Levine S, Henderson W, Lee H, VA CSDM Group. Veterans Affairs Cooperative Study on Glycemic Control and Complications in Type II Diabetes (VA CSDM) Diabetes Care 18:1113-1123, 1995.

Emanuele MA, Emanuele NV. Binge alcohol exposure and testosterone. Science matters 7:53-54, 1995.

Emanuele NV, Emanuele MA. Drugs to treat the tissue complications of diabetes-peripheral neuropathy. Comprehensive Therapy 21:579-582, 1995.

Projects Completed or Active (Selected)

• Brain-Based Prolactin - Further Characterization & Studies
• Brain Prolactin as a Central Neuromodulator
• Glycemic Control and Complications in Non-Insulin Dependent Diabetes Mellitus
• Brain Luteinizing Hormone: A Putative Neuroregulator
• Extra Pituitary Luteinizing Hormone
• TSH in Brain Pituitary: Secretory Interactions
• Effects of EtOH on Neuroendocrinology

Research Funding Sources

• VA Cooperative Studies
• VA Merit Review

Research Methods Employed

• Radioimmunoassay
• Various in vivo and in vitro Bioassays
• Primary Monolayer Anterior Pituitary and Lymphocyte Cell Culture
• Perfusion
• Molecular Biology Techniques (Northern Blotting, Slot Blotting, Western Blotting, Polymerase Chain Reaction)