BIOGRAPHICAL SKETCH

Academic & Professional Background

• M.D. 1980 - University of Chile School of Medicine, Santiago, Chile, South America
• Residency (Internal Medicine) 1984 - Salvador Hospital, University of Chile, Santiage, Chile, South America
• Critical Care Training 1991 - Finch University of Health Sciences, Chicago Medical School, North Chicago, Illinois
• Ph.D. (Physiology and Biophysics) 1994 - Finch University of Health Sciences, Chicago Medical School, North Chicago, Illinois

Current Research Interests

• Cardiopulmonary Resuscitation
• Cardiovascular Physiology
• Myocardial Ischemia
• Ventricular Fibrillation

Selected Publications

Book Chapters

• Gazmuri RJ, Weil MH, Rackow E. Options for Augmenting the Efficacy of Closed-Chest cardiopulmonary resuscitation. In: Ayres SM, Grenvik A, Holbrook PR, and Shoemaker WC (eds). Textbook of Critical Care, 3rd Edition. Philadelphia: WB Saunders, 1995, pp.29-38.
• Gazmuri RJ, Maldonado F. Post-Resuscitation Management. In: Weil MH, Tang W (eds). CPR: Resuscitation of the Arrested Heart. 1st Edition. Philadelphia: WB Saunders, 1999, pp.179-191.
• Gazmuri RJ, Ayoub IM. Myocardial Effects of Sodium-Hydrogen Exchange Inhibition during Resuscitation from Ventricular Fibrillation. In: Dhalla NS, Takeda N, Singh M, and Lukas A (eds). Myocardial Ischemia and Preconditioning. Boston: Kluwer Academic Publishers (In Press).
• Gazmuri RJ, Ayoub IM. NHE-1 Inhibition: A Potential New Form of Treatment for Resuscitation from Cardiac Arrest. In: Karmazyn M (Ed). The Sodium-Hydrogen Exchange. From Molecule to its Role in Disease. Kluwer Academic Publishers (In Press).
• Gazmuri RJ, Ayoub IM. Kolarova J. Inhibition of the Sodium-Hydrogen Exchanger: A Potential New Form of Treatment for Resuscitation from Cardiac Arrest. In: (Ed). Yearbook of Intensive Care and Emergency Medicine. Springer-Verlag (In Press).

Peer-Review

• Gazmuri RJ, Weil MH, Bisera J, Tang W, Fukui M, Mackee D: Myocardial dysfunction after successful resuscitation from cardiac arrest. Crit Care Med 1996; 24:992-1000.
• Gazmuri RJ, Becker J: Cardiac resuscitation: The search for hemodynamically more effective methods. Chest 1997;111:712-723.
• Zamorano B, Escobar E, Gazmuri RJ: Subcellular distribution of prostaglandin-E2 and prostaglandin-F2 alpha in atrial tissue from patients with mitral valve disease. Biol Res 1998;31:343-349.
• Gazmuri RJ, Berkowitz M, Cajigas H: Myocardial effects of ventricular fibrillation in the isolated rat heart. Crit Care Med 1999;27:1542-1550.
• Gazmuri RJ, Deshmukh S, Shah PR: Myocardial effects of repeated electrical defibrillations in the isolated fibrillating rat heart. Crit Care Med 2000;28:2690-2696.
• Gazmuri RJ, Ayoub IM, Hoffner E, Kolarova JD. Successful ventricular defibrillation by the selective sodium-hydrogen exchanger isoform-1 inhibitor cariporide. Circulation 2001;104:234-239.
• Ayoub IM, Brown DJ, Gazmuri RJ. Transtracheal oxygenation: An alternative to endotracheal intubation during cardiac arrest. Chest 2001;120:163-70.
• Kolarova J, Ayoub IM, Yi Z, Gazmuri RJ. Optimal timing for electrical defibrillation after prolonged untreated ventricular fibrillation. Crit Care Med (In Press).
• Ayoub IM, Kolarova J, Yi Z, Trevedi A, Deshmukh H, Lubell DL, Franz MR, Maldonado FA, Gazmuri RJ. Sodium-hydrogen exchange inhibition during ventricular fibrillation: Beneficial effects on ischemic contracture, action potential duration, reperfusion arrhythmias, myocardial function, and resuscitability. Circulation (In Press).

Editorials

• Gazmuri RJ. Airway management during cardiopulmonary resuscitation: A shifting paradigm. Crit Care Med 1999;27:27-28.
• Gazmuri RJ. Buffer treatment for cardiac resuscitation: Putting the cart before the horse? Crit Care Med 1999;27:875-876.
• Gazmuri RJ. Outcome after cardiopulmonary resuscitation: Is age a factor? Crit Care Med 1999;27:2295-2296.
• Gazmuri RJ, Ayoub I. How do you spell basic life support? Crit Care Med 1999;27:2048-2050.
• Gazmuri RJ. Acidosis during cardiac arrest: A manifestation of inadequate perfusion. Crit Care Med 1999;27:2055-2056.
• Gazmuri RJ, Ayoub I. Pressors for cardiopulmonary resuscitation: Is there a new kid on the block? Crit Care Med 2000;28:1236-1237.
• Gazmuri RJ, Ayoub I. Myocardial effects of epinephrine during ventricular fibrillation: Does flow matter? Crit Care Med 2000;28:1678-1679.
• Gazmuri RJ, Shakeri SA. Low-dose vasopressin for reversing vasodilation during septic shock. Crit Care Med 2001;29:673-675.
• Gazmuri RJ. A clinical decision aid was accurate for predicting survival to hospital discharge after in-hospital cardiac resuscitation. Commentary. ACP Journal Club 2001;135:117.
• Gazmuri RJ, Ayoub IM. Shakeri SA. Ventricular fibrillation waveform analysis for guiding the time of electrical defibrillation. Crit Care Med 2001;29:2395-2397.
• Gazmuri RJ, Shakeri SA. Blood transfusion and the risk of nosocomial infection: An underreported complication? Crit Care Med 2002;30:2389-2391.

Projects Completed or Active (Selected)

• Myocardial Acid-Base Changes During CPR
• Extracorporeal Pump Resuscitation After Prolonged Arrest
• Resuscitation After Prolonged Cardiac Arrest
• Myocardial Protection during Cardiac Arrest
• Myocardial Protection during Ventricular Fibrillation

Research Funding Sources

• VA Merit Review
• Finch University of Health Sciences/The Chicago Medical School
• National Institutes of Health
• Pharmaceutical Industry

Research Methods Employed

• Animal Research with Focus on Cardiovascular Physiology
• Left Ventricular Function using transesophageal echocardiography and left ventricular pressure measurements
• Measurement of Systemic and Regional Blood Flow
• Techniques for Experimental CPR in Large and Small Animal Models
• Isolated Rat Heart Preparation

Professional Accomplishments

• 1993-present - Manuscript Reviewer, Critical Care Medicine
• 1991-present - Abstract Reviewer, Society of Critical Care Medicine Educational and Scientific Annual Symposia
• 1990-present - Member, American Federation for Clinical Research
• 1988-1996 - Member, American Association of the Advancement of Science
• 1986 - Member, Chilean Society of Critical Care Medicine
• 1986 - Member, Medical Society of Santiago, Chile
• 1983-1986 - Member, Chilean Medical College

Honors

• 2003 - Research Citation. Society of Critical Care Medicine 32nd Critical Care Congress
• 2003 - Emergency Medicine Specialty Award recipient. Society of Critical Care Medicine 32nd Critical Care Congress
• 2002 - Research Citation (among 6 finalist). Society of Critical Care Medicine 31st Critical Care Congress
• 2001 - Emergency Medicine Specialty Award Recipient, Society of Critical Care Medicine
• 1994 - Honorary Member, Chilean Society of Surgeons
• 1989 - First Prize in Basic Sciences, Society of Critical Care Medicine
• 1988 - Best Poster, Swiss Society of Intensive Care Medicine
• 1984 - Best Scientific Project, Chilean Society of Cardiology