BIOGRAPHICAL SKETCH

Academic & Professional Background

• M.D. 1970 - University of Indonesia, Jakarta
• Fellowship (Cardiology) 1977 - University of Kentucky Medical Center, Lexington
• Postdoctoral Fellowship 1979 - Columbia University, Department of Pharmacology, New York, New York

Current Research Interests

• Extracellular Recording of the Sinus Node and other Cardiac Pacemakers
• Measurements of Extracellular Potassium Concentrations in the Myocardium during Ischemia and Reperfusion
• Measurements of Regional Myocardial Blood Flow using Radioactive Microsphere Technique
• Microelectrode Studies in the Sinus Node, Ventricular and Purkinje Fibers
• Clinical Trials

Selected Publications

Hariman RJ, Louie EK, Krahmer RL Bremner SM, et al. Regional changes in blood flow, extracellular potassium and conduction during myocardial ischemia and reperfusion. J Am Col Cardiol 21:798-808, 1993.

Beckman KJ, Parker RB, Hariman RJ, et al. The hemodynamic and electrophysiologic actions of cocaine: Effect of sodium bicarbonate as an antidote in dogs. Circulation 83:1799-1807, 1991.

Hariman RJ, Hu D, Gallastegui JL, Beckman KJ, Bauman JL. High incidence of remission in patients with incessant ventricular tachycardia discontinued from antiarrhythmic drugs. Am J Cardiol 66:831-836, 1990.

Beckman KJ, Gallastegui JL, Bauman JL, Prechel D, Hariman RJ. The predictive value of electrophysiologic testing in patients with Wolff-Parkinson-White Syndrome. J Am Col Cardiol 15:640-647, 1990.

Hariman RJ, Hu D, Beckman KJ, Gomes JAC, Bauman JL, El-Sherif N. Cryothermal mapping of the sinus node in dogs: A simple method of localizing dominant and latent pacemakers. Cardiovasc Res 23:231-238, 1989.

Hariman RJ, Chen CM. Recording of diastolic slope from the junctional area in dogs with junctional rhythm. Circulation 68:636-643, 1983.

Hariman RJ, Hoffman BF. Effects of ouabain and vagal stimulation on sinus nodal function in conscious dogs. Circ Res 51:760-768, 1982.

Hariman RJ, Hoffman BF, Naylor RE. Electrical activity from the sinus node region in conscious dogs. Cir Res 47:775-791, 1980.

Projects Completed or Active (Selected)

• CONVINCE Trial
• VA-CSP 399: Sotalol vs. Amiodarone in Atrial Fibrillation
• Double-Blind Comparison of the Safety and Efficacy of the Intravenous Form of Torasemide and Furosemide (Lasix) in Patients with Congestive Heart Failure
• Extracellular Potassium Changes During Reperfusion of Ischemic Myocardium
• Reversal of Cocaine Induced Sodium Blockade

Research Funding Sources

• Banes Foundation
• Boehringer Mannheim Pharmaceuticals
• Chicago Heart Association
• DuPont Nemours & Co., Inc.
• Proctor and Gamble
• Searle
• VA Cooperative Studies
• VA Research Advisory Group (RAG)

Research Methods Employed

• Low Pass Recording of Cardiac Electrical Activity
• Measurements of Regional Blood Flow using Radioactive Microspheres
• Microelectrode Studies for Cardiac Electrophysiology
• Potassium Sensitive Electrodes for Extracellular K Measurements
• Programmed Stimulation for Identification of Arrhythmia Mechanisms

Honors

• 1979 - Fellow, American College of Cardiology
• 1980 - Second Prize Winner of Young Investigator Award, American College of Cardiology