BIOGRAPHICAL SKETCH

Academic & Professional Background

• B.A. (Biology) 1979 - Jacksonville University, Jacksonville, Florida
• M.D. 1984 - University of Florida, Gainesville
• Internship/Residency (Internal Medicine) 1987 - University of Texas Medical Branch, Galveston, Texas
• Fellowship (Pulmonary & Critical Care Medicine) 1990 - University of Texas, Houston

Current Research Interests

• Aging
• Clinical Trials
• Control of Breathing
• Patient Ventilatory Interactions
• Pulmonary Physiology
• Respiratory Muscles

Selected Publications

Preas HL, Jubran A, Vandivier RW, Reda D, Godin PJ, Banks SM, Tobin MJ, Suffredini AF. Effect of endotoxin on ventilation and breath variability: Role of cyclooxygenase pathway. Am J Respir Crit Care Med (in press), 2001.

Tobin MJ, Jubran A, Laghi F. Patient-ventilator interaction. Am J Respir Crit CAre Med 163:1059-1063, 2001.

Jubran A, Tobin MJ. Effect of isocapnic hypoxia on variational activity of breath. Am J Respir Crit Care Med 162:1202-1209, 2000.

Parthasarathy S, Jubran A, Tobin MJ. Assessment of neural inspiratory time in ventilator-supported patients. Am J Resp Crit Care Med 162:546-552, 2000.

Jubran A, Parthasarathy S. Hypercapnic respiratory failure during weaning: Neuromuscular capacity versus muscle loads. In: Liberation from Mechanical Ventilation. Manthous C (Ed.), Respiratory Care Clinics of North America 6:385-406, 2000.

Jubran A. Editorial: Is respiratory controller arrhythmia an artifact of a real phenomenon? Eur Respir J 13:1-2, 1999.

Jubran A. Pulse oximetry. Critical Care 3:R11-R17, 1999.

Jubran A. Editorial: Inspiratory flow rate: More may not be better. Crit Care Med 27:670-671, 1999.

Jubran A. Advances in respiratory monitoring during mechanical ventilation. Chest 116:1416-1425, 1999.

Jubran A. Monitoring mechanics during mechanical ventilation. In: Controversies in Critical Care Medicine. Gutierrez G, Taylor DE (Eds.), Seminars in Respiratory and Critical Care Medicine 20:65-79, 1999.

Jubran A. Monitoring patient mechanics during mechanical ventilation. In: Mechanical Ventilation. Tharratt S (Ed.), Critical Care Clinics 14:629-653, 1998.

DeAbate CA, Henry D, Bensch GW, Jubran A, Chodosh S, Tipping D, Talbot GH. Sparfloxacin vs Ofloxacin in the treatment of acute bacterial exacerbation of chronic bronchitis: A multicenter, double-blind, randomized, comparative study. Chest 114:120-130, 1998.

Jubran A, Mathru M, Dries D, Tobin MJ. Continuous recordings of mixed venous oxygen saturation during weaning from mechanical ventilation and the ramifications thereof. Am J respir Crit Care Med 158:1763-1769, 1998.

Parthasarathy S, Jubran A, Tobin MJ. Cycling of inspiratory and expiratory-muscle groups with the ventilator in airflow limitation. Am J Respir Crit Care Med 158:1471-1478, 1998.

Jubran A, Laghi F, Mazur M, Parthasarathy S, Garrity ER, Fahey PJ, Tobin MJ. Partitioning of lung and chest wall mechanics before and after lung reduction surgery. Am J Respir Crit Care Med 158:306-310, 1998.

Brack T, Jubran A, Tobin MJ. Effect of resistive loading on variational activity of breathing. Am J Respir Crit Care Med 157-1756-1763, 1998.

Laghi F, Jubran A, Topeli A, Fahey PF, Garrity ER, Arcidi JM, De Pinto DJ, Edwards LC, Tobin MJ. Effect of lung volume reduction surgery on neuromechanical coupling of the diaphragm. Am J Respir Crit Care Med 157:475-483, 1998.

Tobin MJ, Laghi F, Jubran A. Respiratory muscle dysfunction in mechanically-ventilated patients. Molecular and Cellular Biochemistry 179:87-98, 1998.

Jubran A. Monitory mechanics during mechanical ventilation. RT/The Journal for Respiratory Care Practioners. February/March:65-72, 1998.

Jubran A, Grant BJB, Tobin MJ. Effect of hyperoxic hypercapnia on variational activity of breathing. Am J Respir Crit Care Med 156:1129-1139, 1997.

Leung P, Jubran A, Tobin MJ. Comparison of assisted ventilator modes on triggering, paitent effort and dyspnea. Am J Respir Crit Care Med 155:1940-1948, 1997.

Brack T, Jubran A, Tobin MJ. Effect of elastic loading on variational activity of breathing. Am J Respir Crit Care Med 155:1341-1348, 1997.

Jubran A, Tobin MJ. Passive mechanics of lung and chest wall in patients who failed and succeeded in trial of weaning. Am J Respir Crit Care Med 155:916-921, 1997.

Jubran A, Tobin MJ. Pathophysiologic basis of acute respiratory distress in patients who fail a trial of weaning from mechanical ventilation. Am J Respir Crit Care Med 155:906-915, 1997.

Anzueto A, Jubran A, Ohar JA, Piquette CA, Rennard SI, et al. Effects of aerosolized surfactant in patients with stable chronic bronchitis. JAMA 278:1426-1431, 1997.

Dhand R, Duarte AG, Jubran A, Jenne JW, Fink JB, Fahey PJ, Tobin MJ. Dose response to bronchodilator delivered by metered-dose inhaler in ventilator-supported patients. Am J Respir Crit Care Med 154:388-393, 1996.

Jubran A, Tobin MJ. Monitoring during mechanical ventilation. In: Recent Advances in Mechanical Ventilation. Marini JJ, Nahum A (Eds.). Clinics in Chest Medicine 17:453-473, 1996.

Tobin MJ, Jubran A, Laghi F, Dhand R. Using physilogic end pints to assess innovations in mechanical ventilation. Respir Car 40:971-974, 1995.

Jubran A, Tobin, MJ. Noninvasive respiratory monitoring. In: Critical Care Medicine: Principles of Diagnosis and Management. Parillo JE, Bone RC (Eds.), Mosby Year Book, Inc., Philadelphia, pp. 157-170, 1995.

Tobin MJ, Yang KL, Jubran A, Lodato RF. Interrelationship of breath components in neighboring breaths of normal eucapnic subjects. Am J Respir Crit Care Med 152:1967-1976, 1995.

Jubran A, Van de Graaff W, Tobin MJ. Variability of patient-ventilator interaction with pressure support ventilation in patients with COPD. Am J Respir Crit Care Med 152:126-136, 1995.

Dhand R, Jubran A, Tobin MJ. Efficacy of bronchodilator delivered by metered-dose inhaler in ventilator-supported patients with COPD. Am J Respir Crit Care Med 151:1827-1833, 1995.

Jubran A. Aspiration pneumonia. In: Comprehensive Respiratory Care. Dantzker DR, MacIntyre NR, Bakow ED (Eds.), W.B. Saunders, Co., Philadelphia, pp. 835-845, 1995.

Tobin MJ, Jubran A. Editorial: Oxygen takes the breath away: Old sting, new setting. Mayo Clin Proc 70:403-404, 1995.

Jubran A, Tobin MJ. Monitoring gas exchange during mechanical ventilation. In: Principles and Practice of Mechanical Ventilation. Tobin MJ (Ed.), New York, McGraw Hill, Inc., pp. 919-943, 1994.

Jubran A, Tobin MJ. Weaning from mechanical ventilation. Pulm Crit Care Update 9(30), 1994.

Jubran A, Tobin MJ. Use of flow-volume curves in detecting secretions in ventilator-dependent patients. Am J Respir Crit Care Med 150:766-769, 1994.

Tobin MJ, Jubran A. Pathophysiology of failure to wean from mechanical ventilation. Schweiz Med Wochenschr 124:2139-2145, 1994.

Jubran A, Gross N, Ramsdell J, et al. Comparative cost-effectiveness analysis of theophylline and ipratropium bromide in patients with chronic obstructive pulmonary disease: A three-center study. Chest 103:678-684, 1993.

Lodato RF, Jubran A. Response time, autonomic mediation, and reversibility of hyperoxic bradycardia in conscious dogs. J Appl Physiol 74:634-642, 1993.

Jubran A, D'Alonzo GE, Tobin MJ. The use of mechanical ventilation via a nasal mask in myotonic dystrophy. Tex Med 88(2):73-75, 1992.

Fraire AE, Shahab I, Greenberg SD, Jubran A, Noall M. Experimental polyacrylamine-induced acute injury in rat lung. Chest 102:1591-1594, 1992.

Jubran A, Greenberg SD, Solomon M, Noall MW, Tobin MJ. Inhalation injury secondary to polyacrylamide. Chest 101:576-578, 1992.

Jubran A, Tobin MJ. Effect of hyperinflation on Konno-Mead indices or rib cage-abdominal motion. Am Rev Resp Dis 146:1378-1382, 1992.

Tobin MJ, Jubran A. Difficult weaning. In: Yearbook of Intensive Care and Emergency Medicine. Vincent JL (Ed.), Berlin, Springer-Verlag, pp. 393-398, 1992.

Projects Completed or Active (Selected)

• Androgen Therapy in the Elderly
• Pattern of Breathing
• Weaning from Mechanical Ventilation
• A Randomized, Double-Blind, Multi-Center, Comparative Phase III Study of Oral BMS-284756 vs. Oral Axithromycin in the Treatment of Acute Exacerbation of Chronic Bronchitis
• Hyperoxia-induced Hypercapnia in COPD Patients
• Cardiac Impairment in Patients with Acute Ventilatory Failure
• Double-Blind, Randomized, Comparative, Multicenter Study of Sparfloxacin vs Erythromycin in the Treatment of Community-Acquired Pneumonia
• Randomized, Placebo-Controlled, Dose-Ranging Study of Exosurf in Patients with Chronic Bronchitis
• Multinational, Multicenter, Double-Blind, Placebo-Controlled, Phase III Study to Evaluate the Efficacy and Safety of Aerosolized Recombinant

Research Funding Sources

• Abbott Labs
• AMVET
• Briston-Myers Squibb
• Burroughs Wellcome
• Chicago Lung Association
• Genetech
• Laerdal Foundation for Acute Medicine
• Paragon Biomedical Inc.
• Rhone-Poulec Rorer
• TAP Pharmaceuticals
• Zambon Corporation

Research Methods Employed

• Measuring Pressure Flow in ICU Patients