BIOGRAPHICAL SKETCH

Academic & Professional Background

• B.S. (Biology) 1976 - Northern Illinois University, DeKalb
• Ph.D. (Anatomy) 1982 - Loyola University Medical Center, Maywood, Illinois
• M.D. 1988 - Loyola University Stritch School of Medicine, Maywood, Illinois
• Resident (Neurology) 1992 - Loyola University Medical Center, Maywood, Illinois

Current Research Interests

• Aging
• Neural Plasticity and Recovery of Function
• Neural Transplantation
• Rodent Model for Stroke (Focal Ischemia)

Selected Publications

Z'Graggen WJ, Fouad K, Raineteau O, Metz GAS, Schwab ME, Kartje GL. Compensatory sprouting and impulse rerouting after unilateral pyramidal tract lesion in neonatal rats. J Neuroscience 20:6561-6569, 2000.

Kartje GL, Schulz MK, Lopez A, Schnell L, Schwab ME. Corticostriatal plasticity is restricted by myelin-associated neurite growth inhibitors in the adult rat. Annals of Neurology 45:778-786, 1999.

Wenk CA, Thallmair M, Kartje GL, Schwab ME. Increased corticofugal plasticity after unilateral cortical lesions combined with neutralization of the IN-1 antigen in adult rats. J Comp Neurol 410:143-157, 1999.

Schulz MK, Schnell L, Castro AJ, Schwab ME, Kartje GL. Cholinergic innervation of fetal neocortical transplants is increased after neutralization of myelin-associated neurite growth inhibitors. Exp Neurology 149:390-397, 1998.

Z'Graggen WJ, Metz GAS, Kartje GL, Thallmair M, Schwab ME. Functional recovery and enhanced corticofugal plasticity after unilateral pyramidal tract lesion and blockade of myelin-associated neurite growth inhibitors in adult rats. J Neurosceince 18:4744-4757, 1998.

Thallmair M, Metz GAS, Z'Graggen W, Raineteau O, Kartje GL, Schwab ME. Neurite growth inhibitors restrict plasticity and functional recovery following corticospinal tract lesions. Nature/Neuroscience 1:124-131, 1998.

Schulz MK, Sorenson JC, Tillotson GL, Castro AJ, Zimmer J. The effect of fetal neocortical transplants on lesion-induced cerebral cortex plasticity. Cell transplantation 5:279-286, 1996.

Schulz MK, McNulty JA, Handa RJ, Hogan TP, Tillotson GL, Shaw PL, Zimmer J, Castro AJ. Fetal neocortical transplants grated into neocortical lesion cavities made in newborn rats. An analysis of transplant integration with the host brain. Cell Transplantation 4:1123-1132, 1995.

Tillotson GL, Schulz MK, Hogan TP, Castro AJ. An analysis of fetal neocortical transplants into focal ischemic lesions in adult rats. Neuroscience Letters 201:69-72, 1995.

Tillotson GL, Phillips SG, Coker S, Difazio M. Spinal cord AVM in a 7 year old child. Clin Ped 33:315-317, 1994.

Gupta SR, Tillotson GL. Use of anticoagulation in cerebrovascular disease. Adv Clin Neurosci 4:117-133, 1994.

Schulz MK, Handa RJ, Tillotson GL, Castro AJ. Expression of C-fos mRNA and C-fos protein in neocortical transplants into excitotoxin-induced lesions of adult rats. Exp Neurology 129:321-329, 1994.

O'Donoghue DL, Kartje-Tillotson G, Castro AJ. Forelimb motor cortical projections in normal rats and after neonatal hemicerebellectomy: An anatomical study based upon the axonal transport of WGA/HRP. J Comp Neurol 256:274-283, 1987.

Kartje-Tillotson G, O'Donoghue DL, Dauzvardis MF, Castro AJ. Pyramidotomy abolished the abnormal movements evoked by ICM's. Brain Res 415:172-177, 1987.

Kartje-Tillotson G, Neafsey EJ, Castro, AJ. Topography of corticopontine remodeling after cortical lesions in newborn rats. J Comp Neur 250:206-214, 1986.

Castro AJ, Kartje-Tillotson G, Swenson RS. Disruption of corticospinal plasticity by 6-hydroxydopamine measured by intracortical microstimulation in rats. Dev Brain Res 24:295-298, 1986.

O'Donoghue DL, Kartje-Tillotson G, Neafsey EJ, Castro AJ. A study of forelimb movement evoked by intracortical microstimulation after hemicerebellectomy in newborn, young and adult rats. Brain Res 385:311-320, 1986.

Kartje-Tillotson G, Neafsey EJ, Castro AJ. Electrophysiological analysis of motor cortical plasticity after cortical lesions in newborn rats. Brain Res 332:103-111, 1985.

Projects Completed or Active (Selected)

• Neuronal Transplant on Repair of Stroke Lesions in Adult and Aged Rats
• Analysis of Cortical Plasticity Following Neonatal or Adult Brain Damage
• Recovery of Function after Stroke

Research Funding Sources

• Falk Foundation, Neuroscience and Aging Institute, Loyola University
• VA Career Development Award
• VA Research Advisory Group, VA Merit Award
• National Institutes of Health

Professional Accomplishments

• 1996-1997 - Visiting Professor, Brain Research Institute, University of Zurich, Switzerland

Honors

• 1998-2001 - VA Career Development Awardee
• 1993 - Diplomate of the American Board of Psychiatry and Neurology
• 1991 - Frank A. Rubino Clinical Neurology Award, Loyola University Medical Center, Maywood, IL
• 1987 - American Association of University Women Senior Medical Student Award