BIOGRAPHICAL SKETCH

Academic & Professional Background

• B.Sc. (Biological & Agricultural Sciences) 1962 - Osmania University, India
• M.Sc. (Entomology) 1964 - Osmania University, India
• Ph.D. (Entomology) 1967 - Oklahoma State University, Stillwater
• Postdoctoral Training (Cell Biology) 1968-1969 - University of Chicago, Illinois

Current Research Interests

• Identification of Neurotrophic Factors which Induce the Regrowth of Injured Spinal Cord Axons
• Pathophysiology of Spinal Cord Injury
• Spinal Cord Repair through Application of Small Electric Field
• Spinal Cord Repair through Implantation of Carbon Filaments
• Transplantation of Fetal Spinal Cord to Induce Regeneration of Injured Spinal Cord Axons

Selected Publications

Khan T, Havey RM, Sayers ST, Patwardhan A, King WW. Animal models of spinal cord contusion injuries. Laboratory Animal Science 49:161-172, 1999.

Soneru IL, Khan T, Orfalian Z, Abraira C. Acetyl-L-Carnitine effects on nerve conduction and glycemic regulatio in experimental diabetes. Endocrine Res, 1997.

Kerns JM, Truong TT, Walter JS, Khan T. Do direct current electric fields enhance micturition in the spinal cat? J Spinal Cord Med 19:225-233, 1996.

Walters JS, McLane J, Wuying C, Khan T, Cogan S. Evaluation of a thin film peripheral nerve cuff electrode. J Spinal Cord Medicine 18:27-31, 1995.

Myklebust JB, Cusick JF, Boerboom LE, Prieto TE, Khan T. Vascular effects of spinal cord stimulation in the monkey. Stereotactic and Functional Neurosurg 64:32-39, 1995.

Liu LS, Khan T, Sayers S, Dauzvardis M, Trausch C. Electrophysiological improvement after co-implantation of carbon filaments and fetal tissue in the contused rat spinal cord. Neurosci Lett 200:199-202, 1995.

Sayers S, Khan T, Shahid R, Dauzvardis M, Siegel G. Distribution of alpha 1 subunit isoform of (Na,K)-ATPase in the rat spinal cord. Neurochem Res 19:597-602, 1994.

Khan T, Myklebust JB, Swiontek T. Electric field distribution within normal cat spinal cord. J Neurotrauma 11:563-572, 1994.

Khan T, Myklebust JB, Swiontek T, Sayers S, Dauzvardis M. Electric field distribution within the injured cat spinal cord: Injury potentials and field distribution. J Neurotrauma 1:699-710, 1994.

Khan T, Dauzvardis M, Sayers S. Carbon filament implants used as a substrate for regenerating spinal cord axons. Proceedings of the 14th Annual International Conference of the IEEE Engineering in Medicine and Biology Society 2802-2803, 1992.

Khan T, Dauzvardis M, Sayers S. Carbon filament implants promote axonal growth across the transected rat spinal cord. Brain Res 541:139-145, 1991.

Projects Completed or Active (Selected)

• Enhanced Carbon Filament Prostheses as Substrated for Regrowth of Injured Spinal Cord
• Electric Fields and Carbon Fibers in the Treatment of Spinal Cord Injury
• Electric Field Effects on Slow Axonal Transport Components in SCI
• Treatment of Sciatic Nerve Injury with Gonadal Steroids
• Gonadal Steroids as Rehabilitative Agents after Acute Partial Spinal Cord Injury

Research Funding Sources

• Paralyzed Veterans of America
• VA Rehabilitation Research & Development

Research Methods Employed

• Experimental Spinal Surgery
• Electrophysiological (SSEP and MEP) Recording
• Neuronal Tracing Techniques
• Functional Assessment after SCI
• Substrate Implants
• Electrical Stimulation
• Slot and Northern Blots
• In Situ Hybridization
• Gait Analysis
• Cystometry
• Tissue Culture
• Image Analysis