BIOGRAPHICAL SKETCH

Academic & Professional Background

• B.A. 1957 - Yeshiva College, New York, New York
• M.D. 1961 - University of Miami School of Medicine, Miami, Florida
• Intern 1962 - Mount Sinai Hospital, New York, New York
• Residency (Neurology) 1965 - Mount Sinai Hospital, New York, New York
• 1965-1968 - Research Associate, National Institutes of Health

Current Research Interests

• Aging
• Brain Aging and Neurodegeneration
• NaK-ATPase: Enzymology & Distribution
• Neurochemistry
• Neurodegenerative Diseases
• Neuropathy and Immunology

Selected Publications

Chauhan NB, Siegel GJ, Lee JM. Depletion of glial cell line-derived neurotrophic factor in substantia nigra neurons of Parkinson's disease brain. J Chem Neuroanat 21(4): 277-88, 2001.

Siegel GJ, Chauhan NB. Neurotrophic factors in Alzheimer's and Parkinson's disease brain. Brain Research Rev 33(2-3):199-227, 2000.

Wolozin B, Kellmann W, Rousseau P, Celesia G, Siegel G. Decreased prevalence of Alzheimer Disease associated with 3-hydroxy-3-methyglutaryl coenzyme A reductase inhibitors. Arch Neurol 57:1439-1443, 2000.

Albers RW, Siegel GJ. Membrane transport. In: Basic Neurochemistry, 6th Edition. Siegel GJ, et al (Eds.), Lippincott-Raven, Philadelphia, pp. 95-118, 1999.

Siegel GJ. Inherited diseases of purine metabolism. In: Basic Neurochemistry, 6th Edition. Siegel GJ, et al (Eds.), Lippincott-Raven, Philadelphia, 1999.

Siegel GJ. Linkage of copper and iron metabolism in Basal Ganglia Disorders. In: Basic Neurochemistry, 6th Edition. Siegel GJ, et al (Eds.), Lippincott-Raven, Philadelphia, 1999.

Siegel G. Basic Neurochemistry - Molecular, Cellular and Medical Aspects. Sixth Edition, Editor-in-Chief, 1999.

Siegel GJ, Chauhan NB, Lee JM. Age-related Na,K-ATPase mRNA expression and Alzheimer's disease. In: Progress in Alzheimer's and Parkinson's Diseases. Fisher, et al (Eds.), Plenum Press, New York, pp. 113-119, 1998.

Stubbs EB, Fisher MA, Siegel GJ. Anti-tubulin antibodies in a sensorimotor neuropathy patient after tubulin polymerisation. Acta Neuropathologica 95:302-305, 1998.

Siegel GJ, Chauhan NB, Lee JM. Age-related Na,K-ATPase mRNA expression and Alzheimer's Disease. In: Progress in Alzheimer's and Parkinson's Diseases. Fisher A, Yoshida M, Hanin (Eds.), Plenum, New York, pp. 113-119, 1998.

Chauhan NB, Siegel GJ. Differential expression of Na,K-ATPase alpha-isoform mRNAs in aging rat cerebellum. J Neurosci Res 47:287-299, 1997.

Chauhan NB, Siegel GJ. Age-dependent organotypic expression of microtubule-associated proteins (MAPI, MAP2 and MAP5) in rat brain. Neurochem Res 22:713-719, 1997.

Chauhan NB, Siegel GJ. Na,K-ATPase: Increases in alpha3-messenger RNA levels in aging rat cerebral cortex. Neuroscience, 78:7-11, 1997.

Chauhan NB, Lee JM, Siegel GJ. Na,K-APTase mRNA levels and plaque load in Alzheimer's Disease. J Molec Neuroscience 9:151-166, 1997.

Chauhan NB, Siegel GJ. In situ analysis of Na, K-ATPase 1- and 3- isoform in RNAs in aging rat hippocampus. J Neurochem 66:1742-1751, 1996.

Sayers ST, Khan T, Shahid R, Dauzvardis MF, Siegel GJ. Distribution of alpha 1 subunit isoform of Na,K-ATPase in the rat spinal cord. J Neurochem Res 15:597-602, 1994.

Siegel GJ (Editor-in-Chief), Aganoff BW, Albers RW, Molinoff PD (Eds). Basic Neurochemistry, Raven Press, New York, 1994.

Siegel GJ. Clinical Neurochemistry, editorial overview. Curr Opin Neurol Neurosurg 6:1-5, 1993.

Hieber V, Siegel GJ, Fink DJ, Beaty MV, Mata M. Differential distribution Na,K-ATPase, -isoform mRNAs in the central nervous system. Cell Mol Neurobiol 11:253-262, 1991.

Mata M, Siegel GJ, Hieber V, Beaty MV, Fink DJ. Differential distribution of Na,K-ATPase, -isoform in the peripheral nervous system. Brain Res 546:47-54, 1991.

Mata M, Fink D, Ernst SA, Siegel GJ. Immunocytochemical demonstration of (Na+,K+)-ATPase to internodal axolemma in myelinated fibers of rat sciatic and optic nerves. J Neurochem 57:184-192, 1991.

Sackellares JC, Siegel GJ, Abou-Khalil BW, Hood TW, Gilman S, McKeever PE, Hichwa RD, Hutchins GD. PET studies of lateral and mesial temporal metabolism in epilepsy of mesial temporal origin. Neurol 40:1420-1426, 1990.

Sheedlo HJ, Siegel GJ, Ernst SA. Immunocytochemical localization of (Na+ + K+)-ATPase in the rat hippocampus. Neurosci Lett, 97(1-2):18-22, 1989.

Siegel GJ, Desmond TJ. Effects of tetradecyl sulfate on electrophoretic resolution of kidney Na,K-ATPase catalytic subunit isoforms. J Biol Chem, 264:4751-4754, 1989.

Hieber VC, Siegel GJ, Desmond TJ, Liu-Hwa J, Ernst SA. Na,K-ATPase: Comparison of the cellular localization of a-subunit mRNA and polypeptide in mouse cerebellum, retina, and kidney. J Neurosci Res, 23:9-20, 1989.

Projects Completed or Active (Selected)

• Antibody-Mediated Neutralization of Amyloid Peptide Neurotoxicity in Rodent Models of Alzheimer's Disease
• Neurotrophic Factors in the Aging Nervous System and in Alzheimer's, Parkinson's and other Neurodegenerative Diseases
• Alzheimer's and other Neurodegenerative Diseases: Na, K-ATPase, Immunotherapy
• Gonadotrophic Influences Cytokines, Neurotrophic Factors and Brain Edema and Statins in Alzheimer's and other Age-Dependent Neurodegenerative Diseases

Research Funding Sources

• CARES, Hines VA Hospital
• Falk Foundation, Loyola University

Research Methods Employed

• Brain Fractionation
• ATPase Assays
• SDS - Gel Electrophoresis
• Antibody Production, ELISA, Immunoblot
• In situ Hybridization, Northern Blot, PCR

Professional Accomplishments

• 1979-present - Chief Editor of Basic Neurochemistry, American Society for Neurochemistry

Honors

• 1959 - Goldberger Research Fellowship, AMA Council on Foods and Nutrition, University of Miami, Miami, Florida Member, Alpha Omega Alpha