BIOGRAPHICAL SKETCH

Academic & Professional Background

• M.D. (Medicine) 1959 - Patiala Medical College, Patiala, India
• M.Sc. (Experimental Medicine) 1970 - McGill University

Current Research Interests

• Alcoholism
• Computers in Medicine
• Diabetes
• Neurobiology

Selected Publications

Snyder AK, Singh SP, Zhmann S. Effects of ethanol on substrate uptake and incorporation in primary astrocyte cultures. In: Alcohol and Glial Cell Monograph No. 27. Lancaster F. (Ed), NIH-NIAAA, Bethesda, MD, 1994.

Strivenugopal KS, Singh SP, Yuan X, Ehmann S, Snyder AK. Differential removal of insulin-like growth factor binding proteins in rat serum by solvent extraction prodedures. Experietia 50:451-455, 1994.

Vlichkis ND, DeQuatro V, Douglas J, Svetkey LP, Singh SP, Weidel SC, Chen CR, Woodward DL. Evaluation of the clinical pharmacology of nilvedipine in patients with mild to moderate essential hypertension. J Clin Cardiology 17:263-268, 1994.

Hu I, Singh SP, Snyder A. Effect of ethanol on glucose transporter expression in cultured hippocampal neurons. Alcoholism: Clin Exp Res 19(6):1398-1402, 1995.

Cox MW, Blount JP, Crowe PA, Singh SP. Diabetic patients' alcohol use and quality of life: Relationship with prescribed treatment compliance among older males. Alcoholism: Clin Experimental Res 20(2):327-331, 1996.

Singh LD, Singh SP, Handa RD, Ehmann S, Snyder AK. Effect of ethanol on GLUTl protein and gene expression in rat astrocytes. Metabolic Brain Disease, 11:343-355, 1996.

Singh SP, Ehmann S, Snyder AK. Ethanol induced changes in insulin-like growth factors and IGF gene expression in fetal brain. Proc Soc Exp Biol Med 212:349-354, 1996.

Singh SP, Gao Y, Kunapuli SP, Ravindera R. Role of Gqa in insulin stimulated glucose uptake by C6 Glioma Cells. NeuroReport 8(9-10):2359-2363, 1997.

Singh SP, Handa RK, Depala V, Gao Y, Mellroy PJ, Ravindera R. The effect of ethanol on muscarinic receptor-G protein coupling in the rat cortex. Pharmacology & Toxicology 81:294-299, 1997.

Singh SP, Gao Y, Kunapuli SP, Ravindera R. Glucose uptake by C6 glioma cells is mediated by Gqa. NeuroReport 9:115-119, 1998.

Projects Completed or Active (Selected)

• Antihypertensive and Lipid Lowering Treatments to Prevent Heart Attack Trial Source
• Molecular Biology of Ethanol Effect on Glucose Transporters
• A Placebo-Controlled Safety and Efficacy Study of Pimagedine in Patients with Type II Diabetes Mellitus and Overt Diabetic Nephropathy
• A Randomized Double-Blind, Placebo-Controlled, Six Month Safety and Efficacy Trial of 0.1, 0.5, 1, 2, 5 mg TID of Voglibose (AO-128) in Type II Diabetic Mellitus Patients (non-insulin dependent diabetes)
• A Phase III Randomized, Double-Blind, Placebo-Controlled, Multicenter, Multidose Study of the Combined Effects of Subcutaneously Administered Insulin and rhIGF-I in Subjects with Insulin-Dependent Diabetes Mellitus

Research Funding Sources

• Genetech, Inc.
• Marion Merrill Dow
• National Institutes of Health
• Takeda Laboratories
• VA Cooperative Studies

Research Methods Employed

• Biochemistry
• Clinical Studies
• Molecular Biology
• Radioimmuno Assays

Honors

• 1973 - Fellow, American College of Physicians
• 1990 - Lawrence R. Medoff Award, Finch University of Health Sciences, The Chicago Medical School, North Chicago, IL
• 1994 - Fellowship, American College of Clinical Endocrinologists
• 1997 - Fellowship, American College of Nuclear Medicine