BIOGRAPHICAL SKETCH

Academic & Professional Background

• M.B., B.Ch. (Medicine) 1975 - University College, Dublin, Ireland
• MRCP (Medicine) 1977 - St. Vincent's Hospital, Dublin, Ireland
• M.D. (Thesis) 1986 - University College, Dublin, Ireland

Current Research Interest

• Aging
• Clinical Trials
• Control of Breathing
• Respiratory Abnormalities During Sleep
• Respiratory Muscle Function

Selected Publications

Goode ML, Fink JB, Dhand R, Tobin MJ. Improvement in aerosol delivery with helium-oxygen mixtures during mechanical ventilation. Am J Respir Crit Care med 163:109-114, 2001.

Jubran A, Tobin MJ. Effect of isocapnic hypoxia on variational activity of breath. Am J Respir Crit Care Med 162:1202-1209, 2000.

Parthasarathy S, Jubran A, Tobin MJ. Assessment of neural inspiratory time in ventilator-supported patients. Am J Resp Crit Care Med 162:546-552, 2000.

Laghi F, Topeli A, Tobin MJ. Does resistive loading decrease diaphragmatic contractility before task failure? J Appl Physiol 85:1102-1112, 1998.

Jubran A, Mathru M, Dries D, Tobin MJ. Continuous recordings of mixed venous oxygen saturation during weaning from mechanical ventilation and the ramifications thereof. Am J respir Crit Care Med 158:1763-1769, 1998.

Jubran A, Tobin MJ. Pathophysiological basis of acute respiratory distress in patients who fail a trial of weaning from mechanical ventilation. Am J Respir Crit Care Med 155:906-915, 1997.

Brack T, Jubran A, Tobin MJ. Effect of elastic loading on variational activity of breathing. Am J Respir Crit Care Med 155:1341-1348, 1997.

Laghi F, Harrison M, Tobin MJ. Comparison of magnetic and electrical phrenic nerve stimulation in assessment of diaphragmatic contractility. J Appl Physiol 80:1731-1742, 1996.

Dhand R, Duarte AG, Jubran A, Jenne JW, Tobin MJ. Dose response to bronchodilator delivered by metered-dose inhaler in ventilator-supported patients. Am J Respir Crit Care Med 154:388-393, 1996.

Duarte AG, Dhand R, Reid R, Fink JB, Tobin MJ, Jenne JW. Serum albuterol levels after metered-dose inhaler administration to mechanically-ventilated patients and health subjects. Am J Respir Crit Care Med 154:1658-1663, 1996.

Esteban A, Frutos F, Tobin MJ, et al. A comparison of four methods of weaning patients from mechanical ventilation. N Engl J Med 332:345-350, 1995.

Tobin MJ, Yang KL, Jubran A, Losato RF. Interrelationship of breath components in neighboring breaths of normal eupneic subjects. Am J Respir Crit Care Med 152:1967-1976, 1995.

Laghi F, D'Alfonso N, Tobin MJ. Pattern of recovery from diaphragmatic fatigue over 24 hours. J Appl Physiol 79:539-546, 1995.

Tobin MJ (Ed.). Principles and practice of mechanical ventilation. McGraw Hill, Inc., New York, p. 1300, 1994.

Tobin MJ. Mechanical ventilation. N Engl J Med 330:1056-1061, 1994.

Projects Completed or Active (Selected)

• Double-Blind, Randomized, Placebo-Controlled, Dose-Response of Inhaled Nitric Oxide in ARDS
• The Pattern of Breathing
• Prospective, Double-Blind, Placebo-Controlled, Randomized, Multi-Center North American Study for Safety and Efficacy of Urine Monoclonal Antibody to TNF Mab
• Randomized, Placebo-Controlled Trial of E5 Antiendotoxin Monoclonal Antibody in Patients with Severe Sepsis

Research Funding Sources

• Austrian Medical Council
• Bayer
• Swiss National Science Foundation
• VA Merit Review

Research Methods Employed

• Electromyography
• Esophageal Pressure Measurements
• Inductive Plethysmography
• Polysomnography

Professional Accomplishments

• 1997 - Chair Elect, Critical Care Assembly of American Thoracic Society
• 1996 - Chairperson, Program Committee of Critical Care Assembly, American Thoracic Society
• 1994 - Elected to American Society of Clinical Investigation; The Best Doctors in America
• 1993 - American Editor, Intensive Care Medicine
• 1992 - Associate Editor, American Journal of Respiratory and Critical Care Medicine (formerly American Review of Respiratory Disease)
• 1990-1997 - Editorial Boards: Thorax, Journal of Critical Care, Clinical Pulmonary Medicine

Honors

• 1996 - The 1996 Visiting Professor to Harvard Medical School in Pulmonary & Critical Care Medicine
• 1995 - Visiting Professor, Vanderbilt University, and University of Alabama at Birmingham, and Penn State
• 1993 - Visiting Professor, Yale University School of Medicine, and Mayo Clinic, and University of Zurich
• 1986, 1988, 1989 - Dean's Teaching Excellence List, University of Texas Medical School, Houston, Texas
• 1985-1995 - Chair, Symposia and Scientific Session, American Thoracic Society