BIOGRAPHICAL SKETCH

Academic & Professional Background

• B.Sc. (Biology) 1961 - Jammu and Kashir University, India
• M.B.B.S. (Medicine) 1967 - Government Medical College, Kashir, India
• D.CH. (Pediatrics) 1969 - Punjab University, India
• Fellowship (Pediatric Nephrology) 1974 - Childrens Hospital of Michigan, Wayne State University, Detroit, Michigan
• Fellowship (Internal Medicine Nephrology) 1979 - Rush Medical Center, Chicago, Illinois

Current Research Interests

• Compensatory Hypertrophy
• Hypertensive Microvascular Injury
• Pathogenesis of Hypertension
• Progression of Renal Disease
• Radiotelemetry and Blood Pressure
• Renal Transplantation

Selected Publications

Griffin KA, Picken MM, Churchill M, Churchill P, Bidani AK. Functional and structural correlates of glomerulosclerosis after renal mass reduction in the rat. J Am Soc Nephrol 11:497-506, 2000.

Griffin KA, Picken MM, Bakris GL, Bidani AK. Class differences in the effects of calcium channel blockers in the rat remnant kidney model. Kidney International 55:1849-1860, 1999.

St. Lezin E, Griffin KA, Picken M, Churchill MC, Churchill PC, Kurtz TW, Liu W, Wang N, Pravenec M, Bidani AK. Genetic isolation of a chromosome 1 region affecting susceptibility to hypertension-induced renal damage in the spontaneously hypertensive rat. Hypertens 34:187-191, 1999.

Johnson RJ, Gordon KL, Suga S, Duijvestijn AM, Griffin K, Bidani A. Renal injury and salt sensitive hypertension after exposure to catecholamines. Hypertension 34:151-159, 1999.

Griffin KA, Bidani AK. Calcium-channel blockers and the progression of renal disease. Current Hyptertension Reports 1:436-445, 1999.

Churchill PC, Churchill MC, Bidani AK, Griffin KA, Picken M, Pravenec M, Kren V, St. Lezin E, Wang J-M, Wang N, Kurtz TW. Genetic susceptibility to hypertension-induced renal damage in the rat: Evidence based on kidney-specific genome transfer. J Clin Invest 100:1373-1382, 1997.

deBlois D, van Kleef EM, Schwartz SM, Daemen MJAP, Su JE, Griffin KA, Bidani AK, Lombardi DM. Alpha-adrenergic receptor stimulation increases DNA synthesis in normal but not injured rat arterial wall. Arteriosclerosis, Thrombosis and Vascular Biology 16:1122-1129, 1996.

Griffin KA, Bidani AK. Calcium channel blockers and the progression of renal disease: A double-edged sword. Kidney: A Current Survey of World Literature 5:253-258, 1996.

Bidani AK, Griffin KA. Experimental models of renal mass reduction and their relevance to clinical medicine. Kidney: A Current Survey of World Literature 4:4-9, 1995.

Bidani AK, Griffin KA. Calcium channel blockers and renal protection: Is there an optimal dose? (editorial) J Lab Clin Med 125:553-555, 1995.

Griffin KA, Picken MM, Bidani AK. Deleterious effects of calcium channel blockade on pressure transmission and glomerular injury in rat remnant kidneys. J Clin Invest 96:793-800, 1995.

Churchill PC, Churchill MC, Bidani AK, Rabito SF. Kallikrein excretion in Dahl salt-sensitive and salt-resistant rats with native and transplanted kidneys. Am J Physiol 269:F710-F717, 1995.

Griffin KA, Picken M, Bidani AK. Method of renal mass reduction is a critical determinant of subsequent hypertension and glomerular injury. J Am Soc Nephrol 4:2023-2031, 1994.

Bidani AK, Griffin KA, Plott W, Schwartz MM. Renal ablation acutely transforms "benign" hypertension to "malignant" nephrosclerosis in hypertensive rats. Hypertension 24:309-316, 1994.

Griffin KA, Picken M, Bidani AK. Radiotelemetric BP monitoring, antihypertensives and glomeruloprotection in remnant kidney model. Kidney Int 46:1010-1018, 1994.

Schwartz MM, Evans J, Bidani AK. The mesangium in the long-term remnant kidney model. J Lab Clin Med 124:644-651, 1994.

Schwartz MM, Bidani AK. The role of glomerular epithelial cell injury in the pathogenesis of glomerular scarring in the rat remnant kidney model. Am J Pathol 142:209-219, 1993.

Schwartz MM, Churchill M, Bidani A, Churchill P. Reversible compensatory hypertrophy in transplanted brown Norway rat kidneys: Morphometric characterization. Kidney Int 43:610-164, 1993.

Schwartz MM, Bidani AK. Comparison of glomerular injury in juvenile vs mature rats in a remnant kidney model. J Lab Clin Med 121:348-355, 1993.

Griffin KA, Bidani AK, Ouyang J, Ellis V, Churchill M, Churchill PC. Role of endothelium-derived nitric oxide in the hemodynamic adaptations after graded renal mass reduction. Am J Physiol 264:R1254-R1259, 1993.

Bidani AK, Griffin KA, Picken M, Lansky DM. Continuous telemetric BP monitoring and glomerular injury in the rat remnant kidney model. Am J Physiol 265:F391-F398, 1993.

Churchill MC, Churchill PC, Bidani AK. Effects of cyclosporine in Lewis rats with native and transplanted kidneys. Transplantation 55:1256-1260, 1993.

Bidani AK, Griffin KA, Plott W, Schwartz MM. Genetic predisposition to hypertension and microvascular injury in the remnant kidney model. J Lab Clin Med 121:284-291, 1993.

Churchill PC, Churchill MC, Bidani AK, Dunbar JC, Jr. Streptozotocin-induced renal hemodynamic changes in isogeneic Lewis rats: A kidney transplant study. Am J Physiol 262:H1809-H1817, 1992.

Projects Completed or Active (Selected)

• Pathology of Hypertensive Injury in Remnant Kidneys
• Calcium Channel Blockers and Glomeruloprotection in Remnant Kidneys
• Pathogenesis of Reduced Renal Mass Hypertension

Research Funding Sources

• Astra-Zeneca
• NIH

Research Methods Employed

• Continuous Telemetric BP Recording
• Renal Hemodynamics
• Renal Histopathology and Morphometrics
• Renal Micropuncture
• Renal Transplantation