BIOGRAPHICAL SKETCH

Academic & Professional Background

• B.S. (Biological Sciences) 1972 - Purdue University, West Lafayette, Indiana
• M.D. 1976 - University of Illinois, Chicago

Current Research Interests

• AIDS, Clinical Manifestations, Antiviral Therapy
• Clinical Trials
• Influenza, Epidemiology, Treatment, Rapid Diagnosis
• Polymerase Chain Reaction for Rapid Diagnosis
• Treatment of M. Tuberculosis
• Vancomycin Resistant Enterococcys

Selected Publications

Lentino JR, Pachucki CT, Ramammurthy S, Turner J. Intramaxillary artery-infusion of Amphotericin B for refractory sphenoid sinus aspergilloses. Infections in Medicine (in press), 2001.

Lentino JR, Pachucki CT, Byrne R, Lau MT, Bayer D. A cost effective home-based parenteral antibiotic infusion program for veteran patients. Federal Practitioner 17:10-15, 2000.

Thompson KS, Donzelli J, Jensen J, Pachucki C, Eng AM, Reyes CV. Breast and cutaneous mycobacteriosis diagnosis by fine needle aspiration biopsy. Diagnostic Cytopathology 16:1-5, 1997.

Gutierrez RA, Dawson GJ, Knigge MF, Melvin SL, Heymen CA, Kyrk CR, Young C, Carrick RJ, Schlauder GG, Surowy TK, Dille BJ, Coleman PF, Thiele DL, Lentino JR, Pachucki C, Mushahwar IK. Seroprevalence of GB Virus C and persistence of RNA and antibody. J Med Virol 53:167-173, 1997.

Pachucki CT. The diagnosis of influenza. In: Current Diagnosis. Conn RB, Borer WZ, Snyder JW (Eds.) WB Saunders, Philadelphia pp 166-167, 1996.

Dawson GJ, Schlauder GS, Pilot-Matias TJ, Thiele D, Leary TP, Murphy P, Rosenblatt JE, Simons JN, Markinson FEA, Guitierrez RA, Lentino JR, Pachucki C, Muerhoff AS, Widell A, Tegtmeier G, Desai S, Mushahwar I. Prevalence studies of GB Virus-C infection using reverse transcriptase-polymerase chain reaction. J Med Virol 50:97-103, 1996.

Spruance SL, Pavia AT, Peterson D, Berry A, Pollard R, Patterson TF, et al. Didavosine compared with continuation of Zidovudine in HIV-infected patients with signs of clinical deterioration while receiving Zidovudine: A randomized double-blind clinical trial. Ann Intern Med 120:360-368, 1994.

Patel JA, Pachucki CT, Lentino JR. Synergy of levofloxacin and oxacillin against quinolone-resistant Staphylococcus aureus measured by the time-kill method. Anti Agents and Chemo 37:339-341, 1993.

Pachucki CT. The diagnosis of influenza. Semin Respir Infect 7:46-53, 1992.

Lentino JR, Augustinsky J, Weber TM, Pachucki CT. Therapy of serious skin and soft tissue infection with ofloxacin administered by intravenous oral route. Chemotherapy 37:70-76, 1991.

Lentino JR, Pachucki CT, Holzer TJ, Heynen C, Schaaff D, Schaefer MR, Dorus W. Comparison of radioimmunoprecipitation assay (RIPA) vs Western Blot in the confirmation of enzyme linked immunosorbent assay repeatedly reactive sera for HTLV-I. J Infect Dis 163:1387-1388, 1991.

Lentino J, Pachucki C, Schaaff D, Schaefer M, Holzer T, Heynen C, Dawson G, Dorus W. Seroprevalence of HTLV/II and HIV-infection among male intravenous drug abusers in Chicago. J Acquir Immune Defic Syndr 4:901-909, 1991.

Pachucki CT, Lentino JR, Schaaff D, Schaefer MR, Heynen CA, Holzer TJ, Dawson GJ, Dorus W. Low prevalence of sexual transmission of Hepatitis C in sexual partners of seropositive intravenous drug users. J Infect Dis 164:820-821, 1991.

Dorus W, Schaefer M, Pachucki CT, Schaaff DM, Lentino JR. HIV infection in drug abusers: Research implication of descriptive studies. NIDA Research Monograph 109:101-113, 1991.

Pachucki CT, Pappas SAW, Fuller GF, Krause SL, Lentino JR, Schaaff DM. Influenza A among hospital personnel and patients: Implications for recognition, prevention and control. Arch Intern Med 149:77-80, 1989.

Pachucki CT, Creticos C. Early detection of influenza virus using a fluorometric assay of infected tissue culture. J Clin Micro 26:2664-2666, 1988.

Projects Completed or Active (Selected)

• A Study of the Effectiveness and Tolerability of Weekly Rifapentine Isoniazid for Three Months versus Daily Isoniazid for Nine Months, for the Treatment of Latent Tuberculosis Infection
• CSP #512: A Tri-National Randomized Controlled Trial to Determine the Optimal Management of Patients with HIV Infection for Whom a First and Second-Line Highly Active Antiretroviral Therapy has Failed
• The Evaluation of a Biotin Enzyme Immunoassay and an Indirect Immunofluorescent Assay Using Monoclonal Antibodies for the Rapid Diagnosis of Influenza A and B Infections
• Consequences of HTLV-III Infection for IV Drug Abusers
• Detection and Treatment of Influenza A Infections in High Risk Ambulatory Care Patients
• Double-Blind Comparison of the Efficacy of Continued Zidovudine vs 2'3'-Didoxyinosial (ddI) (BYM-40900) for the Treatment of Patients with AIDS or AIDS-Related Complex and Increasing Symptomatology Despite Treatment with Zidovudine
• A Double-Blind, Randomized Comparative Study of Delavirdine Mesylate (U90152S) in Combination with Didanosine (ddI) cersus ddI Alone in HIV-1 Infected Individuals with CD4 C Counts of Less than 300//m3
• A Double-Blind, Randomized Dose-Response Study of Three Fixed Doses of Delavrdine Mesylate (U90152S) in Combination with Zidovudine (ZDV) vs ZDV Alone in HIV-1 Infected Individuals with CD4 Counts of 200-500/mm3
• Optional, Open Label, Extended Use of Delavirdine Mesylate Treatment in Triple Combination for HIV-1+ Patients who Participated in Other Delavirdine Mesylate Protocols
• Efficacy and Safety of Once Weekly Rifapentine and Isoniazid (INH) Compared to Twice Weekly Rifampin and INH in the Continuation Phase of Therapy for Pulmonary Tuberculosis
• A Double-Blind, Randomized, Placebo Controlled Study of GS4104 (Ro64-0796) in the Treatment of Influenza Infections
• A Double-Blind, Stratified, Randomized, Placebo Controlled Study of Ro64-0796 in the Treatment of Influenza in Chronically Ill Adults
• Linezolid for the Treatment of Methicillin Resistant Staphylococcus aureus (MRSA) Infections: An Evaluator-Blinded Trial Comparing Linezolid with Vancomycin Alone and Vancomycin Followed by Oral Linezolid
• Sensitivity and Specificy of Polymerase Chain Reaction for the Rapid Diagnosis of Influenza on Clinical Specimens
• Trial of Varicella Vaccine for the Prevention of Herpes Zoster and it's Complications
• Treatment of HIV-related Tuberculisis using a Rifabutin-based Regimen
• A Prospective Randomized Double-Blinded Study of the Tolerability of Higher Doses of Rifapentine
• A Non-Comparative Study of the Efficacy of a Largely Intermittent, Six Month Tuberculosis Treatment Regimen Among Patients Who Will Not Receive Isoniazid Due to the Presence of Initial Isoniazid Resistance of Intolerance

Research Funding Sources

• Bristol-Myers-Squibb
• Center for Disease Control and Prevention
• Gilead Pharmaceuticals
• National Institute of Alcohol and Drug Abuse
• Upjohn Pharmaceuticals
• VA Cooperative Study

Research Methods Employed

• Tissue Culture for Viruses
• ELISA
• Polymerase Chain Reaction