Work of Breathing (WOB) represents the work performed by the respiratory muscles to mobilise gases in and out of the lungs ensuring that CO2 removal and O2 delivery appropriately meet systemic metabolic demands. Increased WOB is not recognised by arterial blood gas analysis (a widespread practice when assessing patients in respiratory distress) and, if untreated, risks the development of respiratory muscle fatigue leading to hypoventilation, apnea, and cardiac arrest.
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